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Schematic Illustration of the LINC00167/miR-203a-3p/SOCS3 Axis in Normal RPE Cells and Dedifferentiated RPE Cells
miR-203a-3p binds to both LINC00167 and the 3′ UTR of SOCS3. When expression of LINC00167 is downregulated, an increased amount of miR-203a-3p would bind to the SOCS3 3′ UTR to decrease SOCS3 protein expression in a post-transcriptional way. This would lead to RPE dedifferentiation.
