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. 2020 Jan 14;19:1086–1097. doi: 10.1016/j.omtn.2019.12.039

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© 2020 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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circRNA-miRNA-mRNA Network Construction and Analysis

(A) Schematic of data processing. (B) Volcano plot of 216 differentially expressed circRNAs for embryo versus adult. Criteria are based on |log₂ FC| >1 and p values <0.05. (C) Heatmap of 17 co-expressed circRNAs identified by comparison of embryonic and adult stages. (D) Global view of the circRNA-miRNA-mRNA network in bovine skeletal muscle development, including 17 circRNAs (green diamonds), 18 miRNAs (red circles), and 462 mRNAs (blue squares). (E and F) Advanced bubble chart of GO (E) and KEGG (F) analysis.