Table 2.

Logistic regression analysis with odds ratios for the demographical, clinical & laboratory parameters of SCA patients with ACS and without ACS.

Parameters	Odds Ratio	95% CI		P value
Demography
Age	1.087	0.978	1.208	0.123
Sex (Male)	1.135	0.425	3.032	0.8
Clinical Features:
Prior ACS	1.067	0.615	1.851	0.753
HU therapy	1.109	0.605	2.032	0.658
Chest/Back pain,	3.074	0.899	10.68	0.074
Fever [>37.80°C],	3.965	1.316	11.85	0.014
Cough,	1.690	0.609	4.742	0.321
Tachycardia [>100],	1.366	0.678	2.774	0.389
Hypotension [<80],	1.013	0.988	1.039	0.098
Tachypnea [>25],	4.226	0.896	19.74	0.068
Reduced pulse oximetry
O2 saturation [<95],	8.111	2.689	24.47	0.000
Asplenia,	7.049	1.957	18.68	0.000
Laboratory Parameters:
Median Hb basal,	0.803	0.555	1.161	0.244
Median Hb nadir,	0.535	0.385	0.805	0.003
Median WBC count basal,	1.175	0.991	1.393	0.064
Median WBC count max,	1.236	1.098	1.392	0.000
Median platelet count basal,	1.002	0.998	1.005	0.353
Median platelet count nadir,	0.999	0.996	1.002	0.438
Median retic count,	1.190	0.897	1.579	0.229
Median basal HbF,	0.983	0.875	1.060	0.439
S.LDH at admission,	1.002	1.000	1.004	0.132
S.LDH max,	1.001	1.000	1.003	0.107
CRP at admission	1.000	0.994	1.007	0.964
CRP max	1.005	1.000	1.010	0.071
AST, u/L	1.024	0.995	1.054	0.103
ALT, u/L	1.010	0.990	1.031	0.331
S. bilirubin,	1.024	0.998	1.051	0.069
Interventions:
Simple blood transfusions,	8.514	2.310	31.375	0.001
Exchange blood transfusions,	31.571	4.031	247.26	0.001

Key: HU- hydroxyurea, ACS- acute chest syndrome, Hb- Haemoglobin, WBC- white blood cell count, NIV- non-invasive ventilation, LDH-lactic dehydrogenase, CRP- C-reactive protein, AST- aspartate transaminase, ALT- alanine transaminase.