Table 1.
History of MHT use in relation to patient and tumor characteristics.
| All patients Median (IQR) or no. of patients (%) n = 814 (100%) | Missing n | Never MHT use Median (IQR) or no. of patients (%) n = 381 (46.8%) | Ever MHT use Median (IQR) or no. of patients (%) n = 433 (53.2%) | P-value | |
|---|---|---|---|---|---|
| Ever MHT, yes | 433 (53.2%) | 0 | 433 (100%) | ||
| Duration | 9 | ||||
| <1year | 47 (5.8%) | 0 | 47 (11.1%) | ||
| 1–2 years | 48 (6.0%) | 0 | 48 (11.3%) | ||
| 3–4 years | 64 (8.0%) | 0 | 64 (15.1%) | ||
| 5+ years | 265 (32.9%) | 0 | 265 (62.5%) | ||
| Age at inclusion, years | 63.9 (58.3–69.7) | 0 | 63.0 (56.0–70.4) | 64.3 (59.6–69.2) | 0.09 |
| BMI, kg/m2 | 25.3 (22.8–28.6) | 24 | 26.0 (23.0–29.4) | 24.8 (22.5–27.9) | 0.002 |
| Coffee, ≥ 2 cups per day | 675 (83.2%) | 3 | 319 (83.9%) | 356 (82.6%) | 0.61 |
| Pre-diagnostic smoker, yes | 158 (19.5%) | 2 | 84 (22.2%) | 74 (17.1%) | 0.068 |
| Alcohol abstainer, yes | 86 (10.6%) | 3 | 49 (12.9%) | 37 (8.6%) | 0.044 |
| Oral contraceptives, ever | 533 (65.6%) | 1 | 222 (58.3%) | 311 (72.0%) | <0.001 |
| Nulliparous | 96 (11.8%) | 1 | 41 (10.8%) | 55 (12.7%) | 0.39 |
| Number of children | 2 (1–3) | 1 | 2 (1–3) | 2 (1–3) | 0.35 |
| Age at first child, years | 24 (21–28) | 101 | 24 (21–28) | 24 (21–27) | 0.053 |
| Receptor status | |||||
| ER+ | 722 (88.8%) | 1 | 329 (86.6%) | 393 (90.8%) | 0.059 |
| PR+ | 569 (70.0%) | 1 | 260 (68.4%) | 309 (71.4%) | 0.36 |
| Histological type | 0 | 0.028 | |||
| Mainly no special type | 652 (80.1%) | 316 (82.9%) | 336 (77.6%) | ||
| Mainly lobular | 104 (12.8%) | 36 (9.4%) | 68 (15.7%) | ||
| Other/mixed | 58 (7.1%) | 29 (7.6%) | 29 (6.7%) | ||
| pT (Invasive tumor size) | 0 | 0.82 | |||
| 1 (≤ 20 mm) | 595 (73.1%) | 273 (71.7%) | 322 (74.4%) | ||
| 2 (21–50) | 208 (25.6%) | 102 (26.8%) | 106 (24.5%) | ||
| 3 (51+) | 9 (1.1%) | 5 (1.3%) | 4 (0.9%) | ||
| 4 (muscular or skin involvement) | 2 (0.2%) | 1 (0.3%) | 1 (0.2%) | ||
| Axillary node involvement | 2 | 0.65 | |||
| 0 | 512 (63.1%) | 245 (64.6%) | 267 (61.7%) | ||
| 1–3 | 233 (28.7%) | 103 (27.2%) | 130 (30.0%) | ||
| 4+ | 67 (8.3%) | 31 (8.2%) | 36 (8.3%) | ||
| Histological grade | 0 | 0.014 | |||
| I | 212 (26.0%) | 88 (23.1%) | 124 (28.6%) | ||
| II | 417 (51.2%) | 190 (49.9%) | 227 (52.4%) | ||
| III | 185 (22.7%) | 103 (27.0%) | 82 (18.9%) | ||
| Detection mode | |||||
| screening detected | 518 (63.6%) | 0 | 249 (65.4%) | 269 (62.1%) | 0.34 |