Table 3.
The selection of independent clinical prognostic factors.
| Clinical characteristics | TCGA (N = 310) | Univariable cox | Multivariable cox | ||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Age (years, mean ± SD) | 65.73 ± 12.71 | 0.994 [0.975–1.014] | 5.549E-01 | – | – |
| Gender (Male/Female) | 169/141 | 1.802 [0.885–2.993] | 2.103E-01 | – | – |
| Pathologic M (M0/M1/–) | 226/43/41 | 3.550 [1.969–6.400] | 7.051E-06 | 3.450 [1.107–10.76] | 3.280E-02 |
| Pathologic N (N0/N1/N2) | 180/77/53 | 1.948 [1.449–2.619] | 4.638E-06 | 1.317 [0.749–2.314] | 3.378E-01 |
| Pathologic T (T1/T2/T3/T4) | 8/55/212/35 | 2.461 [1.507–4.019] | 5.105E-04 | 1.775 [1.167–3.259] | 4.640E-02 |
| Pathologic stage (I/II/III/IV/–) | 51/118/88/43/10 | 1.761 [1.329–2.334] | 6.207E-05 | 0.717 [0.334–1.542] | 3.947E-01 |
| Lymphatic invasion (Yes/No/–) | 109/175/26 | 2.401 [0.441–3.997] | 5.247E-02 | – | – |
| Colon polyps history (Yes/No/–) | 78/176/56 | 0.836 [0.443–1.578] | 5.801E-01 | – | – |
| RS model status (High/Low) | 155/155 | 4.396 [2.467–7.832] | 5.164E-08 | 3.793 [2.009–7.161] | 3.940E-05 |
| Recurrence (Yes/No) | 66/244 | – | – | – | – |
| Recurrence free survival time (months, mean ± SD) | 29.66 ± 25.46 | – | – | – | – |
TCGA, The Cancer Genome Atlas; HR, Hazard Ratio; CI, confidence interval.