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. 2019 Nov 15;9(3):387–402. doi: 10.1016/j.jcmgh.2019.10.013

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Bacterial correlations to gene expression in lamina propria phagocytes. Heat map showing the Spearman correlation coefficient (ρ) values of genes expressed in lamina propria phagocytes and phagocyte-associated microbiota. The data represent correlation values obtained from 33 samples collected from inflamed and noninflamed regions of UC (N = 7) and CD (N = 12) patients. Columns correspond to OTUs and rows correspond to genes that had more than 2 correlations with P < .05 without adjusting for false-discovery rate. Scale bar: (left to right) represents a negative correlation in blue to a positive correlation in red. The genes and bacterial OTUs were clustered by Euclidean distance. Cluster A (green) and B (purple) labeled at the nodes of the dendrogram represent group of genes that were expressed significantly more (cluster A) or less (cluster B) in CD11b+ cells from inflamed areas compared with noninflamed areas, respectively. Within the OTU labels, U refers to unclassified, B refers to genus Brevundimonas and A refers to genus Akermensia.