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. 2019 Nov 19;9(3):403–423. doi: 10.1016/j.jcmgh.2019.11.002

Figure 1.

Figure 1

Necroptosis is activated in the intestinal ileum of infants with NEC. (A) Main necroptosis signaling components. Circled P denotes phosphorylation. (B–E) qRT-PCR of RIPK1, RIPK3, MLKL, and TNFα on human tissue from the ileum. Each point represents an individual patient (ie, >20 samples per group as indicated on each graph). The control was healthy premature infant tissue. (E) IHC showing tissue architecture (ie, E-cadherin), proliferation (ie, PCNA), and necroptosis activation (pRIPK3). Arrows highlight necroptotic epithelium. (B–E) Red circles and green circles reflect the same respective sample group cluster. Scale bars: 50 μm. ***P < .001. Ctrl, control.