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. 2020 Jan 15;19:1153–1163. doi: 10.1016/j.omtn.2019.11.037

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Downregulation of circRASSF2 Promotes G1 Arrest and Causes Apoptosis in PTC Cells In Vitro

(A) Flow cytometric analysis showed that knockdown of circRASSF2 caused significant G1 phase cell cycle arrest of TPC-1 cells. (B) Flow cytometric analysis showed that circRASSF2 overexpression increased the G2/M phase percentage and decreased G0/G1 phase percentage of K1 cells. (C) Flow cytometric analysis showed that circRASSF2 knockdown significantly induced apoptosis of TPC-1 cells. (D) Flow cytometric analysis showed that circRASSF2 overexpression decreased the apoptosis of K1 cells.