Figure 7.

circRASSF2 Is Secreted by Exosomes into Serum of PTC Patients

(A) circRASSF2 was secreted into exosomes derived from serum of PTC patients. A representative image of exosome (indicated by red arrows) derived from serum of PTC patients detected from electron microscope. (B) WB showing the expression of TSG101 and HSP70, which are the markers of exosome from purified serum exosome. (C) qRT-PCR for the abundance of circRASSF2 in serum exosomes. The levels of circRASSF2 in serum exosomes from PTC patients were significantly higher than that in normal individuals. (D) The expression levels of circRASSF2 were negatively correlated with that of miR-1178 in the exosomes extracted from serum of PTC patients. All tests were performed at least three times. Data were expressed as mean ± SD. **p < 0.01.