Fig. 1.

TMEM16A expression was increased in cerulein-induced AP and was correlated with IL-6 expression. A. Representative H&E stains of pancreatic tissues of control mice and AP mice. Mice were sacrificed at 6, 12, and 24 h after the last injection of cerulein. Scale bar: 100 μm. B. The pathologic scores of pancreatic tissues in control mice and AP mice at 6, 12, and 24 h after cerulein treatment. n = 6 mice. *p < 0.05 vs control. C. Western blot analysis of TMEM16A expression in the pancreatic tissues of control mice and AP mice at 6, 12, and 24 h after the last injection of cerulein. D. Western blot analysis of TMEM16A expression in control AR42J cells and cells treated with 10 nM cerulein for 6–24 h. n = 3.*p < 0.05 vs control. E, F. ELISA results of the IL-6 levels in the pancreatic tissues (E) and in the serum (F) of control mice and AP mice at 6, 12 and 24 h after cerulein injection. n = 6. *p < 0.05 vs control. G, H. Correlation of TMEM16A with the IL-6 levels in the pancreatic tissues (G) and in the serum (H) of control mice and AP mice at 6, 12 and 24 h after cerulein injection. The association was analyzed using Spearman correlation analysis.