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. 2020 Feb 6;11:119. doi: 10.3389/fimmu.2020.00119

Figure 2.

Figure 2

High serum background binding reduced seropositivity detection in MOG ratio analysis. Patients negative (filled red) by mean (A,B), median (C), and geometric mean (D) MOG ratio analysis had high background binding. There was a negative correlation between background binding and mean or median MOG ratio values (P < 0.0001). (E) ΔMOG values of MOG Ab+ patients reported negative in MOG ratio analysis by 3 or 4 SD (red, Analysis 6a and 7a, respectively) or 10 SD (orange, Analysis 7b). Children (left) and adults (right) negative by MOG ratio analysis had a broad range of MOG Ab titers and fell within the range of ΔMOG values of patients who were positive by MOG ratio analysis. Dotted lines represent the ΔMOG positive threshold 3 SD above controls. Representative data from three experiments are shown. (F) Patients reported negative by MOG ratio median analysis (4 SD, Analysis 7a) clinically presented with MOG Ab-associated phenotypes. P, pediatric patients; A, adults; ADEM, acute disseminated encephalomyelitis; BON, bilateral optic neuritis; CIS, clinically isolated syndrome; LETM, longitudinally extensive transverse myelitis; ON mixed, combination of BON and UON; ON/TM, simultaneous ON and transverse myelitis; relapsing ADEM, multiphasic ADEM (41); TM, transverse myelitis; UON, unilateral optic neuritis.