Table 2.
Association of HbA1c categories with VTE recurrence.
| HbA1c group | HbA1c | n/N | Crude SHR (95%-CI) | p-value | Adjusted SHR (95%-CI) | p-value | |
|---|---|---|---|---|---|---|---|
| All patients | normal range | <5.7% | 56/452 | 1 (reference) | 1 (reference) | ||
| pre-diabetes range | 5.7 to <6.5% | 40/300 | 1.11 (0.74 to 1.66) | 0.617 | 1.07 (0.70 to 1.63) | 0.756 | |
| diabetes range | ≥6.5% | 13/136 | 0.75 (0.41 to 1.38) | 0.353 | 0.73 (0.39 to 1.37) | 0.328 | |
| Patients with history of diabetes | normal range | <5.7% | 3/26 | 0.76 (0.19 to 2.98) | 0.696 | 0.81 (0.22 to 3.00) | 0.754 |
| pre-diabetes range | 5.7 to <6.5% | 6/34 | 1 (reference) | 1 (reference) | |||
| diabetes range | ≥6.5% | 8/79 | 0.62 (0.22 to 1.75) | 0.365 | 0.68 (0.24 to 1.92) | 0.468 | |
| Patients without history of diabetes | normal range | <5.7% | 53/426 | 1 (reference) | 1 (reference) | ||
| pre-diabetes range | 5.7 to <6.5% | 34/266 | 1.08 (0.70 to 1.66) | 0.731 | 1.03 (0.66 to 1.62) | 0.884 | |
| diabetes range | ≥6.5% | 5/57 | 0.67 (0.27 to 1.68) | 0.393 | 0.70 (0.27 to 1.79) | 0.454 |
VTE recurrence was adjusted for age, gender, active cancer, provoked VTE, prior VTE, body mass index and periods of anticoagulation as a time-varying covariate. CI = confidence interval, n = number of events, N = number of patients, SHR = sub-hazard ratio, VTE = venous thromboembolism.