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. 2020 Feb 12;10:2401. doi: 10.1038/s41598-020-59532-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The frequency of extra-intestinal symptoms before and after GFD in 5 patients with NCGS. There were no changes in allergic rhinitis, depression, menstrual disorder, disturbed sleep patterns and ataxia. On the other hand, the patients reported impressive improvement in some symptoms such as fatigue and weakness (P. value = 0.000, P. value = 0.002) and musculo-skeletal pain (P. value = 0.000, P. value = 0.002) in more than half the time of the DBPC trial period. GFD = Gluten-free diet.