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. 2020 Feb 12;10:2477. doi: 10.1038/s41598-020-59408-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DJ-1 reduces RRPs apoptosis. (A) DJ-1 overexpression reduces RRPs apoptosis. Blue indicates DAPI-stained nuclei, while red indicates TUNEL-positive cells. (B) Quantification of TUNEL staining showing that the DJ-1 overexpression group showed lower apoptosis levels than the HG group. (C,D) After DJ-1 overexpression, Bcl-2 protein levels increased, BAX protein levels decreased, and the Bcl-2/BAX ratio increased. All data are presented as means ± SEM(n = 3/group). ^*P < 0.05 vs NC; ^#P < 0.05 vs NC, HG.