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. 2020 Feb 12;10:2477. doi: 10.1038/s41598-020-59408-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased apoptosis of RRPs after Nrf2 silencing. (A) Nrf2 silencing increase apoptosis of RRPs. Blue indicates DAPI-stained nuclei, while red indicates TUNEL-positive cells. (B) Quantification of TUNEL staining showing that RRPs apoptosis was increased after Nrf2 silencing. (C,D) After Nrf2 silencing, Bcl-2 expression was significantly decreased, BAX expression was significantly increased, and the Bcl-2/BAX ratio was decreased. All data are presented as means ± SEM(n = 3/group). ^*P < 0.05 vs NC; ^#P < 0.05 vs HG.