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. 2020 Feb 12;10:2494. doi: 10.1038/s41598-020-59225-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term treatment for 72 h of human cardiac progenitor cells (hCPCs) with low-dose (1 μM) of ticagrelor (Tic) enhances the release of TSG101+ (A; 48KDa MW), CD63 + (B; 52KDa MW) and heat shock protein (HSP)-70 + (C; 70KDa MW) exosomes, but not at higher dose (Tic 10 μM). As shown in panels D–F, adenosine (ADE, 10 μM) per se does not enhance exosome release and its addiction to culture medium counteracts the effects of Tic 1 µM. Adenosine is added in the presence of EHNA (10 μM). Representative images of cropped densitometric bands of proteins TSG101, CD63 and HSP70 are showed in each panel. The full-length blots/gels of panels A–C and D–F are presented in Supplementary Figure 5 panel A and B respectively. All measurements are mean ± SD. *p < 0.05 vs. untreated condition (Vehicle: sterile phosphate buffer solution).