Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 12;10:2494. doi: 10.1038/s41598-020-59225-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

SNS314 mesylate (SNS314 M), an inhibitor phosphorylation of histone H3 at serine 10 (phospho-H3S10), reduces cell viability (A) and proliferation (B) in a dose dependent manner in hCPCs untreated and treated with ticagrelor (Tic 1 μM). Higher dose of SNS314 M (10 μM) counteracts ticagrelor (Tic 1 μM) effects (A,B). SNS314 M 10 μM counteract effects of Tic 1 μM on levels of phospho-H3S10/H3 ratio (C) without altering expression of P2Y₁₂ (D; 52KDa MW) of hCPCs. Levels of phospho-H3S10, H3 and P2Y₁₂ are normalized on glyceraldehyde 3-phosphate dehydrogenase (GAPDH) levels and expressed as arbitrary units (a.u.). Representative images of cropped densitometric bands of proteins phospho-H3S10, H3, P2Y₁₂ and GAPDH are showed in panel E. The full-length blots/gels are presented in Supplemental Fig. 7 panel A. All measurements are mean ± SD. *p < 0.05 vs. untreated condition (Vehicle: sterile phosphate buffer solution); ^#p < 0.05 vs. Tic 1 μM; ^§p < 0.05 vs. SNS314 M (10 μM).