Table 2.
Sensitivity (%), specificity (%), and AUC for total PSA, free PSA, PSA density, PSA-α1ACT, free-to-total PSA ratio (FPR), complexed-to-total PSA ratio (CPR) and FPR/CPR ratio for the 126 patients with PCa and 464 with BB with tPSA between ≥4 and <10 µg/L.
| Assay | Cut-off value | Sensitivity | Specificity | AUC (95% CI) |
|---|---|---|---|---|
| Total PSA, µg/L | >4.04 | 100 | 1 | 0.56 (0.53–0.61)b |
| >4.20 | 95 | 6 | ||
| >4.60 | 90 | 14 | ||
| >4.90 | 85 | 21 | ||
| PSA density | ≤0.78 | 100 | 2 | 0.52 (0.43–0.61) |
| ≤0.55 | 95 | 5 | ||
| ≤0.49 | 90 | 8 | ||
| ≤0.41 | 85 | 14 | ||
| Free PSA, µg/L | ≤3.43 | 100 | 3 | 0.73 (0.68–0.76) |
| ≤2.01 | 95 | 25 | ||
| ≤1.52 | 90 | 45 | ||
| ≤1.42 | 85 | 49 | ||
| PSA-α1ACT, µg/L | >2.25 | 100 | 2 | 0.71 (0.67–0.74) |
| >3.36 | 95 | 18 | ||
| >3.96 | 90 | 34 | ||
| >4.05 | 85 | 36 | ||
| FPR | ≤53 | 100 | 1 | 0.81 (0.78–0.84) |
| ≤27 | 95 | 37 | ||
| ≤23 | 90 | 46 | ||
| ≤19 | 85 | 61 | ||
| CPR | >44 | 100 | 3 | 0.79 (0.75–0.82) |
| >69 | 95 | 35 | ||
| >72 | 90 | 43 | ||
| >79 | 85 | 60 | ||
| FPR/CPR | ≤23 | 100 | 1 | 0.79 (0.76–0.82) |
| ≤6 | 95 | 35 | ||
| ≤5 | 90 | 50 | ||
| ≤4 | 85 | 55 |
aCI, confidence interval; bP < 0.001 for the difference in AUC for total PSA vs all other parameters. P > 0.05 for all other comparisons.