Table 1.

Degree of nodes in type 2 diabetes mellitus subnets. Abbreviations: Dis: disease, Ca: cancer, NOS: not otherwise specified.

		Non-Directed OR ≥ 1.2, Fig. 2	Directed OR ≥ 1.5, Fig. 3a		Directed OR ≥ 2, Fig. 3b
		degree	in-degree	out-degree	in-degree	out-degree
T90	Type 2 diabetes mellitus	37	12	20	4	9
K87	Hypertension complicated	32	12	8
K92	Atherosclerosis/peripheral vascular dis	32	14	13	7	4
D98	Cholecystitis/cholelithiasis	31
F83	Retinopathy	31	11	16	8	6
N94	Peripheral neuritis/neuropathy	31	11	10	5	3
B82	Anaemia other, unspecified	30	12	10
U88	Glomerulonephritis/nephrosis	30	16	13	6	4
F92	Cataract	29
K74	Ischaemic heart dis. with angina	29	8	13
K76	Ischaemic heart dis. without angina	29	13	9	4	3
U99.01	Chronic renal failure	29	15	10
D99	Dis. digestive system, other	28	14	7
K86	Hypertension uncomplicated	28	7	14	3	3
K77	Heart failure	27	15	10
K84	Heart dis. other	27	7	6
K91	Cerebrovascular dis.	27
K89	Transient cerebral ischaemia	26
K82	Pulmonary heart dis.	25	17	6
B81	Anaemia vitamin B12/folate deficiency	24
D97	Liver dis. NOS	24	5	5
K75	Acute myocardial infarction	24	11	10	4	2
K78	Atrial Fibrillation/flutter	24
T99	Endocrine/metabolic/nutrition dis. other	24
T83/82	Obesity/overweight	23	3	10	1	3
T92	Gout	23
K90	Stroke	22	7	8
T89	Type 1 diabetes mellitus	22	2	15	2	8
F84	Macular degeneration	21
P71	Psychosis organic, other	21
T93	Lipid disorder	21	4	6
N93	Carpal tunnel syndrome	15
F93	Glaucoma	14	3	0
D77	Digestive ca. other/NOS	10
X77	Female genital ca., other	10
D76	Pancreas ca.	7	2	2	2	1
B78	Hereditary haemolytic anaemia	5
P72	Schizophrenia	4