Value of the Data •The screening procedure enable the researchers to rapidly identify active natural compounds which can modulate a particular biochemical pathway. •The screening results help to study the interaction/role of a bioactive flavonoid in a particular biochemical process at cellular level and provide preliminary ideas for drug design development •By using this in-silico docking data, novel synthetic analogues with improved bioactivity and minimized side effects can be developed against these targets and research time can be minimized considerably. •We select these 26 flavonoids because these are abundant in nature and well explored. Among these 26 flavonoids, the compounds which shows best affinity for various targets are shortlisted. •The data also useful for research scholars who does not have the sufficient software and hardware requirements which not affordable by them. •Research scholars, researchers in pharmaceutical chemistry can be benefit from the data.