Table 2.
PROTACs 15–23 with the ability to degrade target proteins developed based on cIAP as E3a.
| Compd. | Target | Degradation in cell lines |
Ref. No. (Year) | |
|---|---|---|---|---|
| DC50 | Dmax (%) | |||
| 15 | CRABP-I, –II | NA | NA | 137 (2010) |
| 16 | CRABP-II | NA | NA | 138 (2011) |
| 17 | cIAPI, CRABP-II | NA | NA | 139 (2012) |
| 18 | ER | NA | NA | 140 (2013) |
| 19 | ER | 1–3 nmol/L | >70 | 136 (2017) |
| 20 | ER | 1–0 nmol/L | >80 | 141 (2018) |
| 21 | TACC3 | 10–30 μmol/L | >50 | 145 (2014) |
| 22 | BCR-ABL | 30–100 nmol/L | >70 | 146 (2017) |
| 23 | AR | 1–3 μmol/L | >80 | 147 (2018) |
a
DC50: the concentration at which 50% degradation was observed. Dmax: the maximal level of degradation. NA: not available.