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. 2019 Jul 31;10(2):327–343. doi: 10.1016/j.apsb.2019.07.007

Figure 2.

Figure 2

NOB and its derivatives reverse the resistance of paclitaxel (PTX) to P-gp-overexpressing MDR cancer cells. 29d, 13 and NOB enhanced the anti-proliferative effects of PTX in two drug-resistant cancer cell lines, HCT8/T (A) and A549/T (B), in a dose-dependent manner according to the colony formation assay. The cells were treated with PTX (0.24 μmol/L for A549/T and 0.94 μmol/L for HCT8/T for maintaining the resistance of cancer cells) in the presence or absence of 29d, 13 and NOB at the indicated concentrations.