Figure 6.

Effects of weight and lifestyle intervention on endometrial STC-1 expression. (A) Endometrial STC-1 mRNA expression at cd 21–23 in control women with BMI ≤ 27 kg/m² (N-Ctrl, n = 11) and in controls with BMI > 27 kg/m² (O-Ctrl, n = 5), showing increased endometrial STC-1 expression in O-Ctrl women (P = 0.047). No significant difference in STC-1 mRNA expression was found between the two weight groups of women with PCOS (N-PCOS, n = 5 vs O-PCOS, n = 15). (B) Relative expression of STC-1 on cd 21–23 in women with PCOS and BMI > 27 kg/m² before (O-PCOS, before intervention, n = 14) and after (O-PCOS, after intervention, n = 14) 3-month lifestyle intervention. Lifestyle intervention failed to restore endometrial STC-1 expression. All values are means ± SEM.