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. 2019 Aug 16;10(2):374–382. doi: 10.1016/j.apsb.2019.08.004

Scheme 1.

Scheme 1

Key steps in monoterpene indole alkaloid (MIA) biosynthesis, catalyzed by the enzymes tryptophan decarboxylase (TDC), strictosidine synthase (STR), strictosidine glucosidase (SDG), geissoschizine dehydrogenase (GSD) and sarpagan bridge enzyme (SBE). The pathway diverges after strictosidine aglycone and leads to very different alkaloids in the plants Gelsemium elegans. Several representative alkaloids for Gelsemium elegans are shown.