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The pharmacokinetic profile of 5j.a
| Subject |
t1/2 |
Tmax |
Cmax |
AUC0−t |
AUC0−∞ |
CL |
F |
|---|---|---|---|---|---|---|---|
| (h) | (h) | (ng/mL) | (h·ng/mL) | (h·ng/mL) | (mL/min·kg) | (%) | |
| 5j (i.v., 1 mg/kg) | 0.734 ± 0.174 | – | – | 6647 ± 795 | 6662 ± 809 | 5.06 ± 0.658 | – |
| 5j (p.o., 20 mg/kg) | ND | 13.3 ± 9.24 | 43.23 ± 39.8 | 322 ± 176 | – | – | 0.485 |
–Not applicable.
PK parameters (mean ± SD, n = 3).
