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Graphic illustration of reprogramming human foreskin fibroblasts into iCPCs via SAM-mediated gene activation. The combination of dCas9-VP64, sgRNA and MS2-P65-HSF1 is assembled SAM complex. Targeted and robust activation of endogenous genes, including GATA4, HAND2, MEF2C, TBX5 and MEIS1, can reprogram human fibroblasts toward iCPCs.
