Specifications Table

Subject	Neuroscience (Neurology)
Specific subject area	Neurology
Type of data	Raw volumetric data, Box plots, Radar graph, 3D anatomical figures
How data were acquired	Imaging data were acquired on a Philips Achieva 3T MRI scanner (Philips Medical Systems, Best, The Netherlands) with an 8-channel head coil.
Data format	Raw volumetric brainstem characteristics; medulla oblongata, pons and mesencephalon volume profiles
Parameters for data collection	3D–T1-weighted sequence: spatial resolution: 1 × 1x1mm, Field of view: 256 × 256 × 160 mm, TR/TE = 8.5/3.9 ms, TI = 1060 ms, flip angle = 8°, SENSE factor = 1.5.
Description of data collection	The protocol, consent forms, recruitment procedures, and data management were approved by the institutional ethics committee. All participants provided informed consent prior to inclusion. Participating ALS patients were diagnosed according to the El Escorial research criteria, PLS patients were diagnosed according to the Gordon criteria, FTD patients were diagnosed according to the Rascovsky criteria. MRI data were acquired on a 3 T Philips Achieva system with uniform pulse sequence settings and anonymised.
Data source location	Institution: Computational neuroimaging group, Trinity Biomedical Sciences Institute, Trinity College Dublin City/Town/Region: Dublin Country: Ireland
Data accessibility	Raw brainstem volumes and segmental volumetric profiles have been uploaded to ‘Mendeley Data’ https://doi.org/10.17632/4t8c4bmw5p.3
Related research article	Authors: Peter Bede, Rangariroyashe H. Chipika, Eoin Finegan, Stacey Li Hi Shing, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Siobhan Hutchinson, Colette Donaghy, Russell L. McLaughlin, Orla Hardiman Title: Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: a longitudinal neuroimaging study Journal: Neuroimage Clinical https://doi.org/10.1016/j.nicl.2019.102054