Fig. 4.

Retinoic acid receptor-related orphan receptor A (RORA) participates in the TNF-mediated NF-κB signaling pathway. (a) and (b) Western blots showed that the downstream targets of NF-κB signaling pathway were regulated after RORA overexpression (a) or knockdown (b). (c) and (d) RORA overexpression (c) and knockdown (d) regulated the secretion of proinflammatory cytokines in glioma cells and GSCs as measured by an ELISA. All data are shown as the mean ± SD (from three independent experiments). *P < 0.05; ^⁎⁎P < 0.01; ^⁎⁎⁎P < 0.001.