Fig. 7.

Retinoic acid receptor-related orphan receptor A (RORA) regulates glioma tumorigenesis. (a) and (c) Representative photographs showed that the sizes of intracranial tumors in the coronal position were decreased after RORA overexpression (a), while it increased after RORA was silenced (c). Scale bar = 10 mm. (b) and (d) Kaplan–Meier survival curves showed RORA overexpression shortened the survival times of nude mice (b), while it prolonged the survival times after RORA was silenced (d). For each group, n= = 5. (e) Representative immunohistochemical staining showing the changes in RORA, TNF-α, and Ki-67 after RORA overexpression and knockdown of orthotopic xenograft models. Scale bar = 50 μm. (f) Schematic diagram showing that the downregulation of RORA promoted the proliferation and tumorigenesis of glioma through the TNF-mediated NF-κB signaling pathway. All data are shown as the mean ± SD (three independent experiments). *P < 0.05; ^⁎⁎P < 0.01; ^⁎⁎⁎P < 0.001.