Fig. 1.

Pulmonary vascular remodeling and pulmonary hypertension (PH) in SuHx-exposed rats five weeks after PH induction. (a) Schematic representation of experiment. Briefly, rats received single SU5416 injection and maintained for three weeks under hypoxia (10% O₂) and then for two weeks under normoxia (20% O₂). (b, c) Representative images of hematoxylin and eosin-stained small PAs (b) and PA MT analysis (c). Scale bar: 50 µm; n = 5–6 animals/group; minimum of 12 PA/animal. (d–g) Hemodynamics analysis was performed to measure sRVP (d), mean PAP (e), sLVP (f), and MAP (g) of rats with SuHx-induced PH (five weeks after induction) and age- and gender- matched controls. Data are means ± SE; **p < 0.01 SuHx versus normoxia (Norm); *p < 0.05 SuHx versus normoxia (Norm); “+” indicates mean value.

SuHx: SU5416/hypoxia; PAs: pulmonary arteries; PA MT: pulmonary artery medial thickness; sRVP: systolic right ventricular pressure; PAP: pulmonary arterial pressure; sLVP: systolic left ventricular pressure; MAP: mean arterial pressure.