Table 4.
Identification of potentially significant predictors for the prognosis of sepsis patients.
| Clinical features |
Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P Value | Hazard ratio | 95% CI | P Value | |
| LncRNA CRNDE expression | ||||||
| High vs. low | 4.47 | 1.88–10.66 | 0.001 | 3.43 | 1.15–10.26 | 0.027 |
| miR-181a-5p expression | ||||||
| High vs. low | 0.28 | 0.13–0.64 | 0.003 | 0.41 | 0.15-0.95 | 0.042 |
| Gender | ||||||
| Female vs. male | 1.02 | 0.49–2.10 | 0.961 | 1.86 | 0.77–4.52 | 0.171 |
| Age (yr) | ||||||
| ≥ 56.04 vs. < 56.04 | 1.08 | 0.52–2.22 | 0.839 | 1.26 | 0.53–3.02 | 0.603 |
| MAP score | ||||||
| ≥ 0.34 vs. < 0.34 | 1.60 | 0.72–3.58 | 0.253 | 1.01 | 0.39–2.64 | 0.981 |
| SOFA score | ||||||
| ≥ 7.64 vs. < 7.64 | 3.84 | 1.70–8.68 | 0.001 | 2.84 | 1.09-7.36 | 0.032 |
| APACHE II score | ||||||
| ≥ 17.15 vs. < 17.15 | 5.78 | 2.23–15.00 | < 0.001 | 3.73 | 1.28–10.88 | 0.016 |
| WBC (×109/l) | ||||||
| ≥ 14.37 vs. < 14.37 | 1.33 | 0.63–2.79 | 0.45 | 1.13 | 0.46–2.75 | 0.788 |
| CRP (mg/l) | ||||||
| ≥ 125 vs. < 125 | 1.80 | 0.77–4.23 | 0.178 | 0.59 | 0.19–1.82 | 0.356 |
| PCT (μg/l) | ||||||
| ≥ 9.51 vs. < 9.51 | 1.47 | 0.70–3.11 | 0.312 | 1.22 | 0.50–3.00 | 0.659 |
MAP: mean arterial pressure; SOFA: sequential organ failure assessment; APACHE II: acute physiology and chronic health evaluation II; WBC: white blood cell count; CRP: C-reactive protein; PCT: procalcitonin.