Figure 1.

The potential application for cardiac cell sheet strategies using EiPSC-derived cardiomyocytes. EiPSCs can be differentiated into cardiac progenitor cells, which are then induced to form cardiomyocytes in vitro. These cardiomyocytes can then be organized into a cell sheet and applied to damaged areas of cardiac muscle in vivo via intracoronary or intracardiac injections or epicardially by tissue-engineered cardiac patches. The cell sheets exhibit regenerative capabilities and induce the restoration of cardiac function after muscle damage.