Figure 2.

Topical application of EiPSCs to transected peripheral nerves. After surgical repair of transected peripheral nerves in a mouse sciatic nerve model, axonal regeneration was accelerated by topical application of EiPSCs to the site of injury. The increased production of neurotrophic factor-3 as a growth factor was one of the causes of acceleration of axonal growth and maintenance of muscle function and gait. Compared with negative controls without cell administrations, the regenerated axons exhibited a higher quality of myelination and more cells were obtained.