Figure 3.

The potential for an EiPSC bank. The pluripotent potential of EiPSCs allows them to differentiate into various cell lineages for repair and regeneration. Fibroblasts from healthy donors can be harvested and reprogrammed into EiPSCs and stored in a cell bank. These EiPSCs can then be differentiated into various cell lineages for repair and regeneration according to the needs of individual patients. So far, these cells include cardiomyocytes, hematopoietic progenitor cells, neural cells, adipocytes, and pancreatic islet cells. Each of these cells can be used to replace damaged cells in patients and provide a novel therapeutic potential for each clinical scenario. For any allogeneic transfer of EiPSCs, MHC mismatch typing can first be performed to minimize any chance of MHC mismatch incompatibility before selecting the least antigenic EiPSC bank sample to be transferred to the patient.