Table 1.

Agents that can activate proteasome activity in ischemic stroke models.

Agents	Effects on ischemic stroke	Possible mechanisms	Models	References
Trehalose	Protective	Preservation of proteasome activity	In vitro and in vivo	[22]
Propofol	Protective	Promoting PTEN degradation	In vivo	[23]
NSA	Protective	Promoting MLKL degradation	In vivo	[24]
MicroRNA-124	Protective	Inhibiting the deubiquitinating enzyme USP14 expression and reducing the expression of REST	In vitro and in vivo	[25]
Parkin	Protective	Promotes Drp1 degradation	In vitro	[26]
TRAF6	Detrimental	Ubiquitinating and activating Rac1	In vivo	[27]

Abbreviations: PTEN: phosphatase and tensin homology deleted on chromosome ten; USP14: ubiquitin-specific protease 14; MLKL: mixed lineage kinase domain-like; REST: RE1-silencing transcription factor; Drp1: dynamin-related protein 1; TRAF6: tumor necrosis factor receptor-associated factor 6.