Figure 1.

Architecture of Condensin (SMC2/SMC4) in Plasmodium berghei

(A) Composition of two conventional condensin complexes (condensin I and condensin II), which are composed of heterodimeric core subunits, SMC2 and SMC4, along with non-SMC regulatory subunits: Kleisin and a pair of Heat subunits specific for either condensin I or II. CAP-H, CAP-D2, and CAP-G form the condensin I complex, whereas CAP-H2, CAP-D3, and CAP-G2 form the condensin II complex (modified from Hirano, 2016, and Uhlmann, 2016).

(B) Domain architecture of P. berghei SMC2 and SMC4.

(C) Sequence coverage and amino acid identity of P. berghei SMC2 and SMC4 with H. sapiens, S. cerevisiae, and A. thaliana proteins.

(D) Homology-based predicted three-dimensional structures of P. berghei SMC2 and SMC4 showing coiled backbone extension without the hinge domain but with ATPase head formation, required for condensin complex.

See also Figure S1.