Table 2.

The common response of M. tuberculosis to 6 anti-microbial agents, detailing the genes identified to be up-regulated in response to 3 or more of the anti-microbial compounds tested (maximum 6).

N	Gene name	Rv No	INH	ISO	THL	221	967	9190	Putative function	A	B	C	D	E	F	G	H	I	J
3	pknB	Rv0014c				2	3	3	Serine/threonine protein kinase B								•
4	rpsF	Rv0053		2		2	3	3	Ribosomal protein S6			•
5	icd2	Rv0066c		2	2	3	3	3	Isocitrate dehydrogenase			•					•
3	fbpC2	Rv0129c		4	2			3	Antigen 85c, mycolyl transferase C	•			•
4	pntAB	Rv0156	2	3	2	3			Probable NAD(P) transhydrogenase
4	bglS	Rv0186	2	2			2	3	Probable beta-glucosidase								•
4	Rv0247c	Rv0247c		2	3		3	2	Probable succinate dehydrogenase
3	fadD2	Rv0270	4		2			2	Probable long-chain fatty acid CoA ligase
3	Rv0349	Rv0349	2		2	3			Unknown
3	pknG	Rv0410c		2	2	2			Serine/threoine protein kinase G			•
3	Rv0412c	Rv0412c	2	2		2			Possible conserved membrane protein			•				•
3	Rv0446c	Rv0446c		3		2	2		Possible conserved membrane protein						•
3	icl	Rv0467	4	2				2	Isocitrate lyase						•	•	•		•
3	mmpS2	Rv0506				2	2	3	Unknown, probable membrane protein
3	end	Rv0670	2	2				2	Probable endonuclease IV			•	•			•
4	rpsS	Rv0705		2	2		3	4	30s ribosomal protein s19
4	rpmC	Rv0709		3	2		2	4	50s ribosomal protein L29
3	rplR	Rv0720	4	2				2	50s ribosomal protein L18
3	Rv0851c	Rv0851c				2	2	2	Probable dehydrogenase/reductase						•
4	fadE10	Rv0873	4	4	2		2		Probable acyl-CoA dehydrogenase							•	•
3	Rv0910	Rv0910		2	2	2			Unknown
3	sucC	Rv0951	3	3	2				Probable succinyl-CoA synthetase		•
4	esxl	Rv1037c	4	3			3	3	Putative ESAT-6-like protein								•
5	Rv1109c	Rv1109c	2	3		3	3	2	Unknown							•
3	gltA1	Rv1131	4	2	2				Probable citrate synthase						•	•	•		•
4	narH	Rv1162	2	2		2		2	Probable respiratory nitrate reductase			•					•
3	papA3	Rv1182			3		3	3	Polyketide associated protein				•					•
3	Rv1184c	Rv1184c		2	3		3		Unknown, possible exported protein						•
4	esxK	Rv1197	3	2			3	3	Putative ESAT-6 like protein
4	esxL	Rv1198	4	4			2	4	Putative ESAT-6 like protein
3	atpG	Rv1309		2	2	2			ATP synthase gamma chain
3	PPE19	Rv1361c	4	4			2		PPE family protein
4	appC	Rv1623c	2	2		3		3	Probable cytochrome D ubiquinol oxidase
4	Rv1683	Rv1683	2		2		2	2	Possible long-chain acyl-CoA synthase			•
4	Rv1733c	Rv1733c	4	4			3	4	Probable conserved transmembrane protein			•		•	•
3	narK2	Rv1737c	4	3	2				Possible nitrate/nitrite transporter			•		•	•
4	Rv1738	Rv1738		4		2	2	3	Unknown			•		•	•			•
3	Rv1747	Rv1747		2	2		2		Probable membrane transport protein
4	esxN	Rv1793	3	3			3	3	Putative ESAT-6-like protein
4	Rv1813c	Rv1813c	2	4	2			2	Unknown			•		•	•
4	Rv1987	Rv1987	3		4	3	3		Probable chitinase		•		•
3	ctpF	Rv1997		2	2			2	Probable metal cation transporter			•		•	•
4	Rv1998c	Rv1998c		2	2		2	2	Unknown			•		•
3	Rv2005c	Rv2005c	4	4	2				Unknown			•		•	•			•
3	fdxA	Rv2007c	2	4				2	Probable ferredoxin		•	•		•	•			•	•
6	acg	Rv2032	3	4	2	3	3	4	Unknown, possible nitroreductase			•		•	•
4	Rv2091c	Rv2091c		3		2	3	4	Unknown, probable membrane protein				•			•
3	Rv2147c	Rv2147c		3	2			3	Unknown protein
3	Rv2185c	Rv2185c		2		2		2	Unknown (TB16.3)				•					•
5	cbhK	Rv2202c	3	3	2		2	3	Probable carbohydrate kinase								•
4	fabD	Rv2243	2	4	2	3			Malonyl CoA-acyl carrier transacylase	•	•	•
5	acpM	Rv2244	4	4		4	3	3	Meromycolate extension acyl carrier protein	•	•	•
4	kasA	Rv2245	2	2		2	2		Beta-ketoacyl-ACP synthase	•	•		•
3	htpG	Rv2299c		4	3	3			Probable heat shock protein									•
4	esxO	Rv2346c	3	3			2	4	Putative ESAT-6 like protein
3	Rv2405	Rv2405	2	2		3			Unknown				•
3	ahpC	Rv2428			3	4	3		Alkyl hydroperoxide reductase C	•	•	•			•				•
4	pepD	Rv2467	3	4	2		3		Probable aminopeptidase (pepN)
5	Rv2626c	Rv2626c	3		2	2	2	2	Unknown			•		•	•
3	Rv2627c	Rv2627c		4		2	2		Unknown			•		•	•
3	Rv2629	Rv2629			2	2		2	Unknown			•		•	•
3	sigA	Rv2703				3	2	3	RNA polymerase sigma factor A								•
4	sigB	Rv2710	3		2	2		4	RNA polymerase sigma factor B				•		•	•	•	•
3	recA	Rv2737c		2	2			3	Recombinase A protein
6	35kd_ag	Rv2744c	2	2	2	2	2	3	35-kd alanine rich antigen						•	•	•	•
4	thyX	Rv2754c		2		2	2	3	Probable thymidylate synthase
3	Rv2818c	Rv2818c			3	4	3		Unknown
3	efpA	Rv2846c	4	4	2				Putative efflux protein	•	•
3	Rv2959c	Rv2959c		2	2	3			Possible methyltransferase
5	Rv3049c	Rv3049c		2	2	2	2	2	Probable monoxygenase
3	PPE51	Rv3136	4	2				2	PPE family protein			•
3	rubB	Rv3250c	3	3				2	Probable rubredoxin						•
3	ctpC	Rv3270		2	2			2	Probable metal cation transporter			•				•
3	PE_PGRS52	Rv3388	2	2			2		PE_PGRS family protein
3	PPE60	Rv3478	4	4	2				PPE family protein
3	Rv3592	Rv3592	3	3			2		Unknown (TB11.2)							•
4	panD	Rv3601c	2			2	2	4	Aspartate1-decarboxylase
3	mmpL8	Rv3823c				2	2	2	Conserved large membrane protein
3	papA1	Rv3824c				2	2	2	Polyketide associated protein				•				•
5	esxB	Rv3874		2	2	2	2	2	10 KDa culture filtrate antigen (cfp10)

Numbers in the columns (INH isoniazid, ISO isoxyl, THL tetrahydrolipstatin, SRI# 221/967/9190) indicate the number of statistical tests in which each gene was found to be significantly induced (minimum of 2, maximum 4). The left column labelled N, details the number of drugs in which each gene was significantly differentially expressed. Dots present in the columns A–J indicate that the gene has been previously identified to be up-regulated in response to various other stresses; A INH treatment,¹⁵ B INH and TLM treatment,¹⁶ C low oxygen,³² D nutrient starvation,³⁷ E nitric oxide treatment,³⁵ F phagocytosis,³⁶ G carbon starvation (Hampshire et al., this issue), H detergent stress,³⁴ I heat shock,²³ J acid shock.³³ This table is ordered by Rv number.