Table 4.
Prognostic factors: univariate and multivariate analyses (257 cases).
| Prognostic Variables | No. | Median Overall Survival (OS) | Univariate p-Value |
Multivariate p-Value | Odds Ratio (±CI 95%) |
|---|---|---|---|---|---|
| Performance status (ECOG) | |||||
| 0 | 111 | 11 (7.5–14.8) | 0.029 | n.s. | |
| 1–2 | 35 | 9 (4.9–13.1) | |||
| Unknown | 111 | ||||
| Gastric occlusion-perforation-bleeding | |||||
| No | 153 | 11.2 (8.5–13.8) | 0.002 | n.s. | |
| Yes | 104 | 9 (6.1–11.9) | |||
| Lymphadenectomy | |||||
| D1 | 58 | 6.6 (4.2–8.9) | <0.001 | <0.001 | 0.5 (0.4–0.8) |
| D2 | 116 | 12.4 (10.0–15.0) | |||
| D3 | 83 | 10.9 (6.3–15.5) | |||
| Curativity | |||||
| R0 | 117 | 14.0 (8.8–19.2) | <0.001 | 0.032 | 1.6 (1.1–2.3) |
| R1 | 63 | 8.3 (5.2–11.4) | |||
| R2 | 77 | 7.5 (4.4–10.6) | |||
| Gastric margin | |||||
| Negative | 202 | 12.0 (10.1–13.8) | <0.001 | n.s. | |
| Positive | 55 | 5.4 (4.2–6.6) | |||
| pT | |||||
| 1–2 | 8 | 30.8 (15.9–54.1) | <0.001 | n.s | |
| 3 | 83 | 11.2 (6.8–15.5) | |||
| 4a | 139 | 10.7 (8.8–12.5) | |||
| 4b | 27 | 5 (4.1–5.9) | |||
| pN | |||||
| 0 | 16 | 38 (10.9–65.1) | <0.001 | 0.003 | 1.9 (0.9–4.0) |
| 1 | 24 | 23.9 (0.4–64.4) | |||
| 2 | 34 | 16.0 (5.0–27.0) | |||
| 3a | 86 | 7 (2.5–11.5) | |||
| 3b | 77 | 9.5 (6.4–12.5) | |||
| x | 20 | 10.1 (2.1–18.0) | |||
| Number of resected nodes | |||||
| <16 | 23 | 6 (1.1–10.9) | 0.041 | 0.028 | 0.07 (0.02–0.3) |
| 16–22 | 42 | 5.4 (3.3–7.5) | |||
| 23–29 | 57 | 11.6 (10.2–13) | |||
| 30–44 | 64 | 12.5 (8.1–16.9) | |||
| 45–59 | 53 | 10.2 (0.1–27.2) | |||
| 60–74 | 13 | 15 (0.3–35) | |||
| >74 | 5 | 7.4 (0.1–16.2) | |||
| Histology | |||||
| Intestinal | 103 | 12.5 (10.3–14.6) | 0.015 | 0.023 | 1.7 (1.1–2.5) |
| Diffuse | 116 | 9.4 (6.6–12.2) | |||
| Mixed | 31 | 7.0 (5–8.9) | |||
| Other | 7 | 6.7 (5.2–8.2) | |||
n.b. Variables considered as non-emerging at univariate analysis are listed in Appendix A, Table A1.