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Gene expression profiles of aggressive chemotherapy-resistant rhabdomyosarcoma patient-derived xenografts (Gene Expression Omnibus (GEO) GSE51130 dataset) resemble the stemness-associated gene expression signature identified using our approach. Note the marked downregulation of ALDH1A1 and upregulation of ALDH6A1 in refractory chemoresistant xenografts (red bars; expression for individual biological replicates) compared with the original patient tumor.
