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Principle of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC). During a staging laparoscopy, an aerosol cytostatic agent is applied in the abdominal space using a nebulizer. The application as an aerosol allows the relatively even distribution of the substance. Increased pressure (12 mmHg) ensures deeper penetration into the tissue. Reproduced with permission from [58].
