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. 2020 Jan 4;12(1):131. doi: 10.3390/cancers12010131

Figure 1.

Figure 1

Effect of transient receptor potential melastatin 7 (TRPM7) inhibitors on wildtype human embryonic kidney HEK293 (WT-HEK) and human embryonic kidney HEK293 overexpressing TRPM7 (HEK-M7) cell viability. (A) WT-HEK and HEK-M7 cells proliferated similarly at 24. There was a significant difference in the number of cells at 48 and 72 h, but not 96 h. (B–D) The effect of the TRPM7 inhibitors 2-aminoethyl diphenylborinate (2-APB), ginsenoside Rd (Gin Rd), and waixenicin A (Waix A) on WT-HEK and HEK-M7 viability tested using MTT assay. All three inhibitors tested preferentially inhibited the viability of HEK-M7 over WT-HEK cells. Significant differences (p < 0.05) from the control are indicated by “*”.