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. 2020 Jan 4;11(1):58. doi: 10.3390/genes11010058

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Time kinetics of IRIF. DNA repair foci were measured with: (A) γH2AX, (B) 53BP1, and (C) co-localized γH2AX/53BP1 after irradiation with doses of 0, 5, 10, and 50 cGy. Data show the highest levels at 30 min for: (A) γH2AX foci at all doses; (B) 53BP1 and (C) co-localized γH2AX/53BP1 at 50 cGy. The dose of 50 cGy causes a more rapid decrease in the level of both γH2AX and 53BP1 foci from 30 min to 2 h and then to 22 h as compared to lower doses. This data demonstrates that IRIF induced by low doses (5 and 10 cGy) persist longer than those induced by the higher dose of 50 cGy.