Table 2.
Gene expression signals detected and included in paired analysis.
| Gene | Before ADT (n = 40) (A) | At CRPC Relapse (n = 32) | Pairs Included in Comparison (A vs. CRPC) ** | ||
|---|---|---|---|---|---|
| Detected Signals | Substituted * Missing Signals | Detected Signals | Substituted * Missing Signals | ||
| AGR2 | 30 | 8 | 14 | 18 | 25 |
| AHR | 13 | 24 | 9 | 20 | 13 |
| AKR1C3 | 23 | 17 | 21 | 11 | 24 |
| AR | 23 | 18 | 17 | 14 | 19 |
| ARV7 | 9 | 26 | 10 | 8 | 12 |
| AURKA | 21 | 19 | 19 | 10 | 22 |
| BCL2 | 16 | 23 | 17 | 11 | 21 |
| CDH1 | 22 | 14 | 14 | 15 | 17 |
| CDH2 | 4 | 30 | 4 | 24 | 4 |
| DDR1 | 13 | 23 | 13 | 16 | 14 |
| EGFR | 12 | 9 | 8 | 9 | 9 |
| EMP2 | 22 | 16 | 13 | 17 | 16 |
| EPCAM | 36 | 2 | 23 | 9 | 29 |
| FOLH1 | 30 | 7 | 15 | 14 | 22 |
| UPA | 11 | 25 | 10 | 15 | 13 |
| HER2 | 24 | 16 | 16 | 16 | 21 |
| KLK3 | 33 | 5 | 21 | 11 | 27 |
| KRT19 | 28 | 9 | 17 | 14 | 25 |
| MDK | 29 | 11 | 16 | 15 | 25 |
| POU5F1 | 19 | 20 | 18 | 14 | 22 |
| PSCA | 17 | 20 | 9 | 21 | 14 |
| SNAI1 | 10 | 19 | 4 | 22 | 9 |
| SPINK1 | 20 | 20 | 12 | 20 | 18 |
| SRD5A1 | 25 | 15 | 27 | 4 | 28 |
| TACSTD2 | 29 | 9 | 18 | 8 | 24 |
| TOP2A | 26 | 13 | 18 | 8 | 21 |
| TP53 | 34 | 6 | 28 | 4 | 28 |
| TUBB3 | 21 | 15 | 14 | 16 | 21 |
| TWIST1 | 21 | 17 | 11 | 21 | 19 |
| VEGFA | 24 | 16 | 17 | 15 | 23 |
* Missing signals in samples with too low CTC load for individual genes to be detected are not substituted. ** Pairs need to contain at least one detected signal to be included in analysis.