Figure 6.

Proposed model depicting the role of VosA during ascosporogenesis. In ascospores, VosA plays a variety of roles during ascosporogenesis. First, VosA is required for ascospores viability. Second, VosA directly or indirectly controls mRNA expression of secondary metabolite gene clusters. Deletion of vosA causes an increase in the number of VelB–VeA–LaeA complexes. Third, VosA (or the VosA–VelB complex) positively controls the expression of trehalose synthase genes or negatively regulates the expression of genes associated with β-glucan biosynthesis.