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. 2020 Jan 8;9(1):155. doi: 10.3390/cells9010155

Figure 4.

Figure 4

VE-cadherin, but not Rap1, is essential for Ang-1-induced BAEC migration. (A) Representative images of trajectories of migrating BAECs captured by live-cell imaging during 6 h of migration. BAECs were transfected with control siRNA (siCT) or targeting Rap1 (siRap1) and treated with Ang-1 (100 ng/mL), where indicated. (B,C) Quantifications of total and net cell migration. Graphs are representative of three independent experiments, each yielding similar results. At least 60 cells per experiment were quantified (* p < 0.05). (D–E) BAECs were transfected with control siCT or targeting VE-cadherin (siVE-cadherin), and treated with Ang-1 (100 ng/mL) where indicated, showing quantifications of total and net cell migration. Graphs representative of three independent experiments, each yielding similar results. At least 60 cells per experiment were quantified; * p < 0.05.