Table 2.
Distribution of GBM according to the gene expression profiles (GEP) observed for the EGFR, CDK4, MDM4, and PDGFRA genes.
| GBM Subsets | Gene (FC Cut-Off Value a) |
|||
|---|---|---|---|---|
|
EGFR (2.84) |
CDK4 (1.46) |
MDM4 (1.45) |
PDGFRA (1.70) |
|
| Low/Normal Gene Expression | ||||
| N. of Samples (%) | 35 (42%) | 8 (9%) | 50 (60%) | 35 (42%) |
| FC Values | 1.20 (0.06–2.83) |
1.18 (0.58–1.42) |
0.82 (0.58–1.41) |
0.81 (0.04–1.68) |
| High-Gene Expression | ||||
| N. of Samples (%) | 48 (58%) | 75 (90%) | 33 (40%) | 48 (58%) |
| FC Values | 17.08 | 3.10 | 1.76 | 3.28 |
| (2.89–251.9) | (1.55–272.3) | (1.46–25.23) | (1.71–102.5) | |
| p-Value * | <0.001 | <0.001 | <0.001 | <0.001 |
a FC (fold change) cut-off values shown between brackets were set at the 95 percentile values observed in normal brain tissue samples; * Comparison of gene expression levels by the Mann–Whitney U test. Results expressed as number (percentage) of cases or as median (range) FC values.