Table 3.
Association between the copy number (CN) status and gene expression profile of the EGFR, CDK4, MDM4, and PDGFRA genes in GBM.
| CN Status (N. Cases and Percentage) |
Gene Expression Profile of GBM | ||||
|---|---|---|---|---|---|
| Low/Normal Expression | High Expression | p-Value | |||
|
AmpEGFR (n = 83) |
No
(64%) |
N. of Cases (%) | 28 (53%) | 25 (47%) | |
| FC | 1.14 (0.22–2.32) |
6.93 (2.89–76.74) |
<0.001 | ||
|
Yes (36%) |
N. of Cases (%) | 7 (23%) | 23 (77%) | ||
| FC | 1.67 (0.06–2.83) |
46.02 (7.45–251.94) |
<0.001 | ||
| p-Value | 0.10 | <0.001 | 0.01 * | ||
| AmpCDK4 (n = 68) |
No (82%) |
N. of Cases (%) | 4 (7%) | 52 (93%) | |
| FC | 1.13 (0.58–1.40) |
3.27 (1.55–117.40) |
<0.001 | ||
| Yes (18%) |
N. of Cases (%) | 1 (8%) | 11 (92%) | ||
| FC | 1.2 (1.2) |
10.57 (1.57-89.07) |
<0.001 | ||
| p-Value | 1 | 0.08 | 0.87 * | ||
| AmpMDM4 (n = 68) |
No (91%) |
N. of cases (%) | 38 (61%) | 24 (39%) | |
| FC | 0.86 (0.27–1.41) |
1.76 (1.46–5.65) |
<0.001 | ||
| Yes (9%) |
N. of cases (%) | 2 (33%) | 4 (67%) | ||
| FC | 0.96 (0.55–1.36) |
12.09 (1.74–25.23) |
<0.001 | ||
| p-Value | 0.85 | 0.02 | 0.18 * | ||
| AmpPDGFRA (n = 68) |
No (93%) |
N. of Cases (%) | 26 (41%) | 37 (59%) | |
| FC | 0.63 (0.04–1.55) |
3.27 (1.71–66.88) |
<0.001 | ||
| Yes (7%) |
N. of Cases (%) | 1 (20%) | 4 (80%) | ||
| FC | 0.16 (0.16) |
3.34 (2.77–102.47) |
<0.001 | ||
| p-Value | 0.25 | 0.51 | 0.35 * | ||
CN: copy number; FC: fold change; *: Pearson Chi-Square test for comparison of patient distribution. Results expressed as number of cases (percentage) or as median FC values (range).