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. 2019 Dec 18;12(1):9. doi: 10.3390/cancers12010009

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A 44-year-old patient with DLBCL involving the mediastinal, hilar, and lower neck lymph nodes. At interim restaging after three cycles of R-CHOP, the initially strong [18F]FDG uptake had dramatically decreased in all nodal regions, with only some hilar and mediastinal lymph nodes (blue arrowhead) still showing slightly higher uptake than the liver (i.e., Deauville 4 with reduced uptake), which fulfills the Lugano criterion for PR. Since the size of the lymph nodes, including the dominant bulk in the mediastinum, had clearly decreased by >30%, this also represented PR according to RECIL. At EOT, the [18F]FDG uptake was now lower than that of the liver and mediastinal blood pool (i.e., Deauville 2), fulfilling the CR criteria of both Lugano and RECIL.