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. 2019 Dec 19;12(1):19. doi: 10.3390/cancers12010019

Figure 3.

Figure 3

Oncogenic activation of the STAT3 pathway in T-cell lymphoma. Constitutive activation of STAT3 and STAT5, which can be driven by the common gamma chain (γc) receptor-dependent cytokines IL-2, -4, -7, -9, -15, and -21, is pervasive in diverse T-cell malignancies [121]. In PTCL and NKTCL, activating mutations in STAT3, JAK1, and JAK3, and loss of function mutations in SOCS-1 and p53 enhance oncogenic effects of STAT3 and STAT5 by promoting cancer cell survival, modulating the tumor microenvironment and facilitating tumor immune evasion [44].