Table 2.

Multivariable Cox regression model for disease free survival and overall survival at five years follow-up.

Outcome of interest	Complete Cases Model			Missing Data Multiple Imputation
Disease Free Survival Model	N = 135 Events = 30			N = 174 Events = 40
	Hazard Ratio	Lower-Upper 95% CI	p-value	Hazard Ratio	Lower-Upper 95% CI	p-value
MOR expression	0.791	0.603–1.039	0.092	1.062	0.930–1.212	0.376
First postoperative 96 h transfusion (yes)	0.991	0.392–2.503	0.985	1.060	0.701–1.603	0.784
ASA (Reference category = 1)
2	0.707	0.155–3.223	0.654	0.854	0.427–1.710	0.657
3	0.936	0.195–4.481	0.934	0.994	0.475–2.080	0.986
4	1.322	0.159–11.007	0.796	0.517	0.129–2.069	0.351
Preoperative Hemoglobin (g∙dL−1)	1.043	0.846–1.287	0.693	1.012	0.919–1.117	0.807
Number of affected lymph nodes	1.283	0.921–1.788	0.141	1.028	0.780–1.322	0.828
CEA at diagnosis (U∙mL−1)	1.811	1.245–2.635	0.002	1.058	0.877–1.28	0.557
Age (years)	1.010	0.970–1.052	0.638	1.005	0.987–1.022	0.591
Overall survival model	N = 135 Events = 29			N = 174 Events = 40
MOR-1 expression	1.023	0.784–1.335	0.869	1.031	0.906–1.173	0.645
First postoperative 96 h transfusion (yes)	1.556	0.658–3.682	0.314	1.004	0.670–1.503	0.986
ASA score (Reference category = 1)
2	0.954	0.119–7.629	0.965	0.898	0.479–1.685	0.737
3	1.948	0.247–15.357	0.527	1.072	0.538–2.138	0.843
4	2.375	0.208–27.07	0.486	0.832	0.183–3.786	0.812
Preoperative Hemoglobin (g∙dL−1)	0.911	0.729–1.139	0.415	1.016	0.925–1.115	0.743
Number of affected lymph nodes	1.482	1.110–1.978	0.008	0.971	0.774–1.218	0.800
CEA at diagnosis (U∙mL−1)	1.485	1.017–2.170	0.041	1.031	0.859–1.24	0.746
Age (years)	1.031	0.989–1.074	0.147	1.003	0.986–1.020	0.746

MOR-1 expression is introduced in both models as a 0 to 6 ordinal variable. The effect estimate is thus to be interpreted as the difference in hazard in the monitored time period when MOR-1 expression increases one level.